This paper closely follows the report of 3D structural-DNA technique that demonstrated a way to build closed boxes from single-layer origami sheets (in a sense, the first folded DNA origami). What the new technique adds to the engineering toolkit is a way to bundle DNA helices into sturdier structures, and to use those structures as building blocks for yet larger structures.
We anticipate that our strategy for self-assembling
custom three-dimensional shapes will provide a general route to the
manufacture of sophisticated devices bearing features on the nanometre
This is a further step toward the development of a methodology for building atomically precise self-assembled structures in which DNA forms an addressable framework for organizing other components (nanotubes, quantum dots, proteins…) into functional systems (circuits, sensors, fabrication tools…). Tom LaBean himself has been a pioneer in developing these DNA-based composite systems.